Why do proteins use selenocysteine instead of cysteine?
نویسندگان
چکیده
منابع مشابه
Selenocysteine in proteins-properties and biotechnological use.
Selenocysteine (Sec), the 21st amino acid, exists naturally in all kingdoms of life as the defining entity of selenoproteins. Sec is a cysteine (Cys) residue analogue with a selenium-containing selenol group in place of the sulfur-containing thiol group in Cys. The selenium atom gives Sec quite different properties from Cys. The most obvious difference is the lower pK(a) of Sec, and Sec is also...
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Since the recent discovery of selenocysteine as the 21st amino acid in protein, the field of selenium biology has rapidly expanded. Twelve mammalian selenoproteins have been characterized to date and each contains selenocysteine that is incorporated in response to specific UGA code words. These selenoproteins have different cellular functions, but in those selenoproteins for which the function ...
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ژورنال
عنوان ژورنال: Amino Acids
سال: 2010
ISSN: 0939-4451,1438-2199
DOI: 10.1007/s00726-010-0602-7